Rb (retinoblastoma) and other proteins that negatively regulate the cell cycle are sometimes called tumor suppressors. Why do you think the name tumor suppressor might be an appropriate for these proteins?

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 anothers question regarding retinoblastoma (Rb)

refers below:

   Rb (retinoblastoma) and other proteins that negatively regulate the cell cycle are sometimes called tumor suppressors. Why do you think the name tumor suppressor might be an appropriate for these proteins?

Tumor suppressor genes and proteins are negative gene regulators that prevent the formation of tumor cells responsible for cancer also called as anti-oncogenes. These genes when go through mutations can cause uncontrolled growth of genes. Tumor suppressor genes will slow down the division of cells and also repairs the DNA damage. These gene will also regulates the programmed cell death. Besides, the tumor suppressor gene also keeps the cell from dividing too fast or too slow. The word suppressor itself give the meaning to suppress or slowing down; hence it is relevant that retinoblastoma protein (Rb) and other proteins such as p53(cyclin inhibitors) are called tumor suppressor because their mechanism works to suppress the tumor-producing genes. It also stated in some biology pages that they were given this name because they reverse, at least in cell culture, the action of known oncogenes.

References:

Tumor Suppressor Genes. 11 November 2017 from, http://www.biology-pages.info/T/TumorSuppressorGenes.html

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